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ÍSLENSKA
3T3-NRU-ljóseiturhrifaprófun
ENSKA
3T3 NRU phototoxicity test
DANSKA
3T3 NRU-fototoksicitetstest
FRANSKA
essai de phototoxicité 3T3
ÞÝSKA
3T3-NRU-Fototoxizitätstest
Svið
íðefni
Dæmi
[is] 3T3-NRU-ljóseiturhrifaprófun í glasi reyndist hafa forspárgildi um bráð ljóseiturhrif í lífi hjá dýrum og mönnumcf.

[en] The in vitro 3T3 NRU phototoxicity test was shown to be predictive of acute phototoxicity effects in animals and humans in vivo.

Skilgreining
[en] this Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light (OECD library, úr Test No. 432: In Vitro 3T3 NRU Phototoxicity Test)

test used to identify the phototoxic effect of a test substance induced by the combination of test substance and light and is based on the comparison of the cytotoxic effect of a test substance when tested after the exposure and in the absence of exposure to a non-cytotoxic dose of UVA/vis light. Cytotoxicity is expressed as a concentration-dependent reduction of the uptake of the vital dye - Neutral Red. (IATE);

the 3T3 Neutral Red Uptake Phototoxicity Test 83T3 NRU PT) is designed to detect the phototoxicity induced by the combined action af a chemical and light by usind an in vitro cytotoxicity assay with the Balb/c 3T3 mouse fibrroblast cell line. The test identifies compounds that act in vivo phototoxic after systemic application, as well as compounds, including UV filter chmicals, that act as photoirritants after topical application and distribution to the skin (ECVAM)

Rit
[is] Reglugerð framkvæmdastjórnarinnar (EB) nr. 440/2008 frá 30. maí 2008 þar sem mælt er fyrir um prófunaraðferðir samkvæmt reglugerð Evrópuþingsins og ráðsins (EB) nr. 1907/2006 um skráningu, mat, leyfisveitingu og takmarkanir að því er varðar efni (efnareglurnar (REACH))
[en] Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)

Skjal nr.
32008R0440
Athugasemd
[is] Sjá Íðorðasafn lækna á vef Árnastofnunar (e. phototoxicity)
[en] The ''3T3'' designation refers to the abbreviation of "3-day transfer, inoculum 3 x 105 cells. This cell line was originally established from the primary mouse embryonic fibroblast cells that were cultured by the designated protocol, so-called ''3T3 protocol'' (Wikipedia)

Orðflokkur
no.
Kyn
kvk.
ENSKA annar ritháttur
3T3 NRU PT
3T3 Neutral Red Uptake Phototoxicity Assay